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add to favorites ... nanjing Other Email:teresa@chembj.com Pharmaceutical Intermediates CAS 81409-90-7 Cabergoline Treatment of Uterine Fibroid
Email:teresa@chembj.com Pharmaceutical Intermediates CAS 81409-90-7 Cabergoline Treatment of Uterine Fibroid


Quick Detail:

Product Name Cabergoline
Synonyms 6-allyl-n-[3-(dimethylamino)propyl]-n-(ethylcarbamoyl)ergoline-8-carboxamide;CABERGOLINE;(8-beta)-(2-propenyl);n-(3-(dimethylamino)propyl)-n-((ethylamino)carbonyl)-6-ergoline-8-carboxamid;FCE-21336,Cabaser,Dostinex;(8b)-N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propen-1-yl)- ergoline-8-carboxamide;Cabaser;Dostine
CAS NO 81409-90-7
MF C26H37N5O2
MW 451.6
Purity >99%
Storage temp Store at +4°C
Appearance White Crystalline Solid
Lead time Within 24 hours upon receipt of payment
Shipment EMS, DHL, TNT, FedEx, UPS
Deliver time Within 24 hours upon receipt of payment
Brand NJBN STEROID
Product Categories Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;API
Usage A dopamine D2-receptor agonist.
 
Product Description:

1.Dostinex (Cabergoline) is a dopamine agonist. Dopamine is a chemical, found in the brain, which transmits nerve impulses and is involved in the formation of epinephrine. More likely than not, this is why the Life-Extentionistas are very big on this drug. Dopamine is also released by the hypothalamus, and hormone can inhibit the release of prolactin from the anterior lobe of the pituitary, so given all the bad things that we have already seen to be a result of excess. If you use anabolic steroids, Dostinex will help you reduce the chance of any of these prolactin related side-effects.
2.It has actually been shown in numerous studies to have a very high success rate in lowering prolactin and prolactin related conditions and side-effects.In fact, for management of hyperprolactinemia and it's symptoms , Dostinex is the preferred treatment in terms of effectiveness as well as having very few undesirable side effects.It does this very well for both men and women, it should be noted…almost identically actually Since it lowers prolactin very efficiently, Dostinex will even get rid sexual dysfunction caused by excess prolactin (which is (anecdotally at least) highly correlative with the use of certain steroids like the Nandrolones and Trenbolones (Deca and Tren). This is great news for everyone who loves Tren and Deca, because those two steroids are really great additions to almost any cycle- but many people avoid using them because of the possibility of them causing impotence (often called "deca dick").

Application:

1)hyperprolactinemia
2)adjunctive therapy of prolactin-producing pituitary gland tumors (prolactinomas);
3)monotherapy of Parkinson's disease in the early phase;
4)combination therapy, together with levodopa and a decarboxylase inhibitor such as carbidopa, in progressive-    phase Parkinson's disease;
5)in some countries also: ablactation and dysfunctions associated with hyperprolactinemia (amenorrhea, oligomenorrhea,anovulation, nonpuerperal mastitis and galactorrhea);
6)treatment of uterine fibroids.adjunctive therapy of acromegaly, cabergoline has low efficacy in suppressing growth hormone levels and is highly efficient in suppressing hyperprolactinemia that is present in 20-30% of acromegaly cases; growth hormone andprolactin are similar structurally and have similar effects in many target tissues, therefore targeting prolactin may help symptoms when growth hormone secretion can not be sufficiently controlled by other methods;


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add to favorites ... nanjing Other Email:teresa@chembj.com Weight Loss 566-19-8 Oral Anabolic Steroid 7-Keto-Dehydroepiandrosterone for Increaring Metabolism
Email:teresa@chembj.com Weight Loss 566-19-8 Oral Anabolic Steroid 7-Keto-dehydroepiandrosterone for Increaring Metabolism


Quick Detail:

Product Name:7-Keto-dehydroepiandrosterone
Alias: 7-Hydroxydehydroepiandrosterone, 5-Androstene-3b-ol-7,17-dione
Purity : 98.5%min
CAS Registry Number: 566-19-8
Grade : Pharmaceutical Grade
Storage: Shading, confined preservation
Brand Name:NJBN STEROID
Delivery time :within 18 hours upon receipt of payment
Delivery: EMS, DHL, TNT, FedEx, UPS
Usage :  It is the intermediate of synthesizing male hormone and female hormone. It is often used as the acetate ester prodrug 7-Keto-DHEA acetate. 7-Keto is marketed as a dietary supplement with the implication that it may accelerate weight loss, increase metabolism, enhance memory, or prevent age-related changes. When used in a topical (skin lotion) product 7-Keto caused long-lasting changes in the body's levels of testosterone, epitestosterone, estradiol, and other steroid hormones

Application:

1.7-Keto-DHEA (also known as 7-Keto, 7-ketodehydroepiandrosterone, or 7-oxodehydroepiandrosterone) is a steroid produced by metabolism of the prohormone dehydroepiandrosterone (DHEA). It is often used as the acetate ester prodrug 7-Keto-DHEA acetate.

2.7-Keto is unique among other derivatives of DHEA because of its oxygenated 7-position. This molecular configuration imparts different characteristics to the molecule, and research reveals that 7-Keto DHEA has multiple distinct effects in the body.Such as, Increased metabolism/weight loss, Age-related immune enhancement.


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add to favorites ... nanjing Other Email:teresa@chembj.com Levonorgestrel Progesterone Hormones Inhibiting Steroid CAS 6533-00-2 Norgestrel for Ovulation
Email:teresa@chembj.com Levonorgestrel Progesterone Hormones Inhibiting Steroid CAS 6533-00-2 Norgestrel for ovulation 
 

Quick Details:

Product Name Norgestrel
CAS NO 6533-00-2
Assay 99%
Mol File 6533-00-2.mol
storage temp 2-8°C
Appearance White Solid
MF C21H28O2
MW 312.45
EINECS 212-349-8
Packaging Detail foil bag or tin or customerized
Storage Shading, confined preservation
Related Substances Pharmaceutical Grade
Brand NJBN STEROID
Synonyms OVRETTE(R);NORPLANT;NORGESTREL;NORGESTREL(LEVO);17-ALPHA-ETHYNYL-18-HOMO-19-NORTESTOSTERONE;18,19-DINOR-13-BETA-ETHYL-17-BETA-HYDROXY-4-PREGNEN-20-YN-3-ONE;18,19-DINOR-4-PREGNEN-20-YN-3-ONE;13BETA-ETHYL-17ALPHA-ETHYNYL-17BETA-HYDROXYGON-4-EN-3-ONE
Usage it is an excellent progestational and ovulation inhibiting steroid. The bioactive enantiomer is levorotatory. Progestogen; oral contraceptive.
 
Product Description:

1."Norgestrel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

2.Norgestrel is a combination drug that contains female hormones that prevent ovulation (the release of an egg from an ovary). This medication also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.

3.Norgestrel is a prescription drug that treats birth control and menstrual irregularity. The original cash price of Norgestrel is not available. If your insurance does not cover this cost, use our Norgestrel coupon to reduce the price. Choose if you would like to receive your Rebates prescription coupon by mail, email, text, or print. Continue reading below for more information on Norgestrel.

4.Norgestrel is a progestin drug that contains a mixture of two medicines such as dextro-norgestrel and levonorgestrel. The active content of Norgestrel is levonorgestrel. Norgestrel is used as a hormonal contraceptive and sometimes an emergency contraceptive. Norgestrel works by preventing ovulation to occur hence prevents fertilization of the egg.
 
Applications:

1.This medication is used to prevent pregnancy. It is often referred to as the "mini-pill" because it does not contain any estrogen. Norgestrel (a form of progestin) is a hormone that prevents pregnancy by changing the womb and cervical mucus to make it more difficult for an egg to meet sperm (fertilization) or for the fertilized egg to attach to the wall of the womb (implantation). Regular use of the "mini-pill" prevents the release of an egg (ovulation) in about half of the women who use it.

2.While the "mini-pill" is more effective than certain other methods of birth control (e.g.,condoms, cervical cap, diaphragm), it is less effective than estrogen/progestin birth control because it does not consistently prevent ovulation. It is usually used by women who cannot take estrogen. For the most effective results, it is very important to take this medication exactly as prescribed.


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add to favorites ... nanjing Other Email:teresa@chembj.com CAS 2482-00-0 Pharmaceutical Raw Materials Agmatine Sulfate for Muscle Growth
Email:teresa@chembj.com CAS 2482-00-0 Pharmaceutical Raw Materials Agmatine sulfate for Muscle Growth


Quik Details:
 
Product Name: Agmatine sulfate
Alias:  (4-Aminobutyl)guanidinium sulphate, 1-Amino-4-guanidinobutane sulfate salt
CAS No.: 2482-00-0
MF:C5H14N4 H2SO4C5H16N4O4S
EINECS No.: 219-617-3
Molecular Formula: 
Assay:98% Min
Appearance: White crystalline powder
Grade Standard:Cosmetic Grade,Food Grade,Medicine
Package: 25kg/drum
 
Description:
 
1.Agmatine sulfate ((4-Aminobutyl) guanidine Sulfate; 1-Amino-4-guanidinobutane) is a byproduct of arginine through the process of decarboxylation. This changes the nature of the amino acid, and allows agmatine to be a jack of all trades.There are two crucial benefits of argmatine sulfate for the bodybuilder and gym rat alike!
 
2.Primarily, the gym-goer is interested in the support of nitric oxide production. Agmatine is a support system of nitric oxide production-much like a necessary spotter for that 1 rep max bench press-by assisting the production of optimal levels of NO.The second way agmatine is the go-to-guy for NO, is that it acts as an inhibitor of nitric oxide synthase-an enzyme which prevents the production of NO. With this one-two punch, nitric oxide levels can be peaked for optimal athletic performance.
 
3.Increasing NO leads to massive pumps in the weight room, better blood flow throughout training, and increased nutrient delivery.Once training has come to an end, the all important recovery phase begins. Here's where agmatine sulfate comes to the rescue again! By supporting nitric oxide production, taking agmatine sulfate after intense training may promote vasodilation and lead to increased nutrient delivery; ideally, agmatine should be taken right after your workout with a supplement or meal containing protein and carbs.When nutrients can be delivered to working muscle tissue faster, you get optimal recovery and muscular growth.
 
4.Besides the obvious muscular benefits, agmatine may also assist with positive psychological attributes. Studies have suggested that agmatine may support neuroprotective effects by providing support against excessive levels of glutamate.Continued research suggests more and more benefits of this awesome supplement. Only time with truly reveal all the benefits to the athlete, gym-goer, and fitness enthusiast alike.
 
Application:
 
Agmatine sulfate can help athletes in a myriad of ways. Agmatine has been suggested to assist with numerous athletic needs, including pre-workout training and post-workout recovery. This leads to more intense workouts and faster recuperation times after the taxation of intense training.But that's just the beginning! The benefits list goes on and on, including:
1)Enhanced insulin production leading to better insulin respons
2)May assist with relief of anxiety leading to reduced cortisol levels
3)Supports nitric oxide production
4)Supports nutrient delivery to muscles
5)Acts in antioxidant function by providing support against free radical damage
6)Assists with stimulating the release of pituitary hormones such as luteinizing hormone (LH) 
7)May help to support heart; brain and vasculature function
8)Promotes a healthy and positive mood


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add to favorites ... nanjing Other Email:teresa@chembj.com Without Side Effect 65277-42-1 Ketoconazole for Antifungal Treatment
Email:teresa@chembj.com Without Side Effect 65277-42-1 Ketoconazole for Antifungal Treatment


 Quick Detail:

Product Name Ketoconazole
CAS NO 65277-42-1
Synonyms ,3-dioxolan-4-yl)methoxy)phenyl)-,cis-;fungarest;fungoral;ketoconazol;ketoderm;ketoisdin;kw-1414;nizoral
Purity 99%
MF C26H28Cl2N4O4
MW 531.43
mp  146°C
EINECS 265-667-4
Appearance White Powder
Brand NJBN STEROID
Price Negotiated
Shipment EMS, FedEx, TNT, DHL, UPS
Delivery within 1 day after we get the payment
Product Categories Active Pharmaceutical Ingredients;Organics;Antifungals for Research and Experimental Use;Antitumors for Research and Experimental Use;Biochemistry;Antibiotic Explorer;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API;API's;Antifungal;Heterocycles;Isotopically Labeled Pharmaceutical Reference Standard;KETOZOLE
Usage For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
 
Product Description:

1.Ketoconazole is a broad-spectrum antifungal imidazole with commercially available product being under the trade name of Jindakening, Meikangling and keNing. It interferes with the activity of fungal cytochrome P-450 with a high selectivity, thus inhibiting the biosynthesis of ergosterol in fungal cell membrane. It is effective in treating both shallow, deep fungal infections and can inhibit both fungal growth and the transition from spores to mycelium to prevent the further infection. It has antifungal effect on Candida genus, Fonsecaea, Coccidioides, Histoplasma, Sporothrix spp and Trichophyton. Clinically, it is suitable for the treatment of ringworm, athlete's foot, and skin ringworm, tinea, jock itch, and thrush, tinea versicolor as well as cutaneous candidiasis. 
2.Ketoconazole lotion, as a skin external use, is mainly used for clinical treatment and prevention of various kinds of infections caused by Malassezia such as tinea versicolor, seborrheic dermatitis and scalp pityriasis (dandruff), and can quickly alleviate the desquamation and itching caused by seborrheic dermatitis and scalp pityriasis.

Application:

1. Pharmacology: ketoconazole belongs to azole-class antifungal drugs and has antifungal activity against various kinds of genus of deep fungal infections such as Candida, Fonsecaea, Coccidioides, Histoplasma, Sporothrix spp as well as Trichophyton. However, this product has a relative weak activity against Aspergillus, Sporothrix schenckii as well as some species of Dermateaceae and Mucor. This product, through actively interfering with the activity of cytochrome P-450, is capable of inhibiting the biosynthesis of the major steroids - ergosterol of the fungal cell membrane. Therefore, it destroys the fungal cell membrane and changes its permeability, resulting in the leakage of important intracellular material. Ketoconazole can also inhibit the biosynthesis of fungal triglyceride and phospholipid biosynthesis, inhibit the activity of oxidase and peroxidase, causing accumulation of intracellular hydrogen peroxide which further leads to cell submicroscopic structural degeneration and necrosis. For candida albicans, it can also suppress the transition process from spores to aggressive mycelium. 
2. Toxicology: Long-term animal toxicity experiments have showed that ketoconazole can significantly increase the level of alkaline phosphatase and cause liver cell degeneration.
 


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add to favorites ... nanjing Other Anti Estrogen Steroid Sex Drugs Primobolan CAS 434-05-9 99% Methenolone Acetate for Bulking Cycle
Anti Estrogen Steroid Sex Drugs Primobolan CAS 434-05-9 99% Methenolone Acetate for Bulking Cycle


Quick Detail:

Product Name:Methenolone Acetate
Synonyms: primobolone;1(5a)-androsten-1beta-methyl-17beta-ol-3-one Acetate
CAS Registry Number:434-05-9
EINECS: 207-097-0
Assay: 99% min.
Grade : Pharmaceutical Grade
Molecular Formula: C22H32O3
Molecular Weight: 344.4877
Character: White crystalline powder.
Delivery time :within 24 hours upon receipt of payment
Delivery: EMS, DHL, TNT, FedEx, UPS
Keywords : bodybuilding , steroid hormone , raw material powder  
Usage: pharmaceutical material, Steroid hormone, Anabolin. As a male hormone and anabolic hormones.

Applications:

1.Methenolone Acetate is the injectable version of the steroid methenolone powders.The effective dose of Primobolan (Methenolone Acetate) in the type of injection is 200-300 mg weekly. In case you want to take this drug by mouth, 50-150 mg in a day is the directed measure. For men, 50-100 mgs /day is the accurate as well actual measure by mouth, while for women, 10-25 mgs /day is the finest quantity. If you have to administrate them as injections, the top dose for Primobolan (Methenolone Acetate) injection is 350-600 mg/week for men. Women have to use 100 mg weekly of this medication. Primobolan (Methenolone Acetate) injectable active life is near ten-fortheen days, while the dynamic life of this medicine in the form of pills is approximate 4-6 hours. The time of its finding is four-five weeks

2.It is the same compound as the one in Primobolan Orals (methenolone acetate), both produced by Schering. In this injectable version, an enanthate ester is added to the steroid, which makes for a slow and gradual release from the site of injection. Its length of activity would thus be quite similar to Testosterone enanthate, with blood levels remaining elevated for approximately two weeks. Methenolone itself is a long acting anabolic, with extremely low androgenic properties.
 
 3.It's anabolic effect is also quite mild, its potency is considered to be slightly less than Deca Durabolin (nandrolone decanoate) on a milligram for milligram basis. For this reason, Primobolan is most commonly used during cutting cycles when a mass increase is not the main goal. Some athletes do prefer to combine a mild anabolic like "Primo" with bulking drugs such as Dianabol, Anadrol, or testosterone however, presumably to lower the overall androgen dosage and minimize uncomfortable side effects. When choosing between Primobolan versions, the injectable is preferred over the oral, as it is much more cost effective.
 
4.Primobolan (Methenolone Acetate) is void of the typical C17-alpha alkylation common in nearly all oral anabolic steroids, and therefore Primobolan presents no measurable hepatotoxic effects on the body. Oral Primobolan has failed to demonstrate any changes in liver enzyme values that would be cause for concern. Primobolan in particular does possess in its own right a resistance to hepatic metabolism and breakdown, and only one incidence of a death resultant of hepatotoxicity and liver failure from oral Primobolan has been recorded in one male elderly individual who was prescribed the compound for the purpose of treating anemia. Therefore, higher doses of oral Primobolan can indeed be utilized but it must be noted that oral Primobolan does still possess a measure of resistance to metabolism and breakdown in the liver, and therefore the risk of hepatotoxicity from Primobolan must not be completely ignored, especially as doses of the oral format are increased to higher and higher amounts.
 

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add to favorites ... nanjing Other Email:teresa@chembj.com Cancer Therapy Supplement Natural Powder CAS 319460-85-0 Axitinib
Email:teresa@chembj.com Cancer Therapy Supplement Natural Powder CAS 319460-85-0 Axitinib 

 
Quick Detail:

Product Name Axitinib
Synonyms AXITINIB;Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-;N-M
ETHYL-2-{[3-((E)-2-PYRIDIN-2-YLVINYL)-1H-INDAZOL-6-YL]SULFANYL}BENZAMIDE;N
Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide;AVERMECTINB;Axitinib for research;AG 013736;N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide
CAS NO 319460-85-0
MF C22H18N4OS
MW 386.47
Storage Shading, confined preservation
Assay >99%
Grade Pharmaceutical Grade
Character Off-White Solid
Drug Class Injectable Anabolic Androgenic Steroid
Brand NJBN STEROID
Delivery time Within 24 hours upon receipt of payment
Shipping EMS, DHL, TNT, FedEx, UPS
Usage Axitinib is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.
 
Product Description:
 
1.Axitinib is also called by its brand name Inlyta. It is a type of drug called a tyrosine kinase inhibitor, which is a cancer growth blocker. It blocks certain proteins called tyrosine kinases from acting on cells. Tyrosine kinases signal to cancer cells to grow.Axitinib blocks different types of tyrosine kinase and is called a multi kinase inhibitor. It stops cancer cells forming blood vessels, which the cancer needs in order to grow. This is called anti angiogenesis treatment.Axitinib is a treatment for advanced kidney cancer. You may also have it as part of a clinical trial for other cancers including soft tissue sarcoma and thyroid cancer.

2.Axitinib interferes with the growth of some cancer cells.Axitinib is used to treat advanced kidney cancer.Axitinib is usually given after other cancer medicine has been tried without success.Axitinib may also be used for purposes not listed in this medication guide.Axitinib dose-dependently inhibits tumor growth in MV522 with ED50 value of 8.8 mg/kg twice daily, based on the relationship between dose and the corresponding TGI (tumor growth inhibition).

3.Axitinib is an oral tyrosine kinase inhibitor selective for vascular endothelial growth factor (VEGF) receptors -1, -2 and -3 that is used in the therapy of advanced renal cell carcinoma.  Axitinib therapy is commonly associated with transient elevations in serum aminotransferase that are generally mild and asymptomatic.  Axitinib has yet to be linked to instances of clinically apparent acute liver injury.
 
Applications:
 
1.Axitinib is indicated for kidney cancer. Axitinib is a kinase inhibitor shown to inhibit the vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, and VEGFR-3) implicated in angiogenesis and tumor growth leading to cancer progression.Affygility Solutions has an occupational exposure limit (OEL) and control band assignment for this active pharmaceutical ingredient (API). This monograph also contains the acceptable daily exposure (ADE) value.

2.The AXIS trial was a phase 3 randomized trial that showed the efficacy of this drug. In this study it was showed that axitinib may increase progression-free survival (PFS) compared to sorafenib in patients with metastatic renal cell carcinoma who previously had failed to first-line therapy with sunitinib, bevacizumab plus interferon-alfa, temsirolimus, or cytokines. 389 patients (54%) had received 1 prior sunitinib-based therapy, 251 patients (35%) had received 1 prior cytokine-based therapy (interleukin-2 or interferon-alfa), 59 patients (8%) had received 1 prior bevacizumab-based therapy, and 24 patients (3%) had received 1 prior temsirolimus-based therapy. The baseline demographic and disease characteristics were similar between the axitinib and sorafenib groups with regard to age (median 61 years), gender (72% male), race (75% white and 21% Asian), and Eastern Cooperative Oncology Group (ECOG) performance status (55% 0, 45% 1), and histology (99% clear cell)

3.In this study they recruited 723 patients (median age 61 years) with metastatic renal cell carcinoma; they were randomized (1:1) without blinding to axitinib 5mg (N = 361) twice daily versus sorafenib 400mg (N = 362) twice daily; allocation concealment was not done. All patients had renal clear-cell carcinoma that progressed despite first-line therapy with sunitinib, bevacizumab plus interferon-alfa, temsirolimus, or cytokines. Increased Axitinib dose was allowed for patients without hypertension or adverse reactions

4.Progression free survival (PFS) was defined as time from randomization to either first documentation of disease progression (per independent blinded radiology review of images) or death due to any cause. The median duration of axitinib therapy was 6.4 months and sorafenib therapy was 5 months. Disease progression or relapse occurred in 160 patients (44%) in axitinib group and 180 patients (50%) in sorafenib group. There was a statistically significant advantage for axitinib over sorafenib for the endpoint of PFS. There was no statistically significant difference between the arms in OS. Comparing axitinib versus sorafenib in intention-to-treat analysis, the PFS was 6.7 months in the axitinib group versus 4.7 months in the sunitinib group; hazard ratio was 0.665 (95% CI 0.544-0.812); one-sided P < 0.0001, and the objective tumor response was 19% versus 9% respectively (P = 0.0001, NNT 10)
 

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add to favorites ... nanjing Other Good Quality 148-01-6 Pharmaceutical Manufacturer Veterinary Mequindox for Feed Additive
Good Quality 148-01-6 Pharmaceutical Manufacturer Veterinary Mequindox for feed additive


 Quick Detail:

Product Name Mequindox
CAS NO 148-01-6
Appearance White powder
25KG/barrel,10kg/barrel 25KG/barrel,10kg/barrel
MW 598.08
MF C32H36ClNO8
EINECS 200-035-3
Synonyms SEROPHENE;PERGOTIME;CLOMPHID;CLOMID;CLOMIFENECITRATE;CLOMIPHENE CITRATE;CLOMIPHENE CITRATE SALT;-[4-(2-CHLORO-1,2-DIPHENYLETHENYL)
Place of origin China
Package 1kg/aluminium foil bag or as required
Shipping EMS , DHL , TNT , FedEx , UPS
Delivery time within 24 hours upon receipt of payment.
Use Used as a feed additive
 
 Product Description:

1.Mequindox, a quinoxaline-N-dioxide derivative that possesses antibacterial properties, has been widely used as a feed additive in the stockbreeding industry in China. While recent pharmacological studies have uncovered potential hazardous effects of mequindox, exactly how mequindox induces pathological changes and the cellular responses associated with its consumption remain largely unexplored. In this study, we investigated the cellular responses associated with mequindox treatment.

2.We report here that mequindox inhibits cell proliferation by arresting cells at the G2/M phase of the cell cycle. Interestingly, this mequindox-associated deleterious effect on cell proliferation was observed in human, pig as well as chicken cells, suggesting that mequindox acts on evolutionarily conserved target(s). To further understand the mequindox-host interaction and the mechanism underlying mequindox-induced cell cycle arrest, we measured the cellular content of DNA damage, which is known to perturb cell proliferation and compromise cell survival.

3.Accordingly, using γ-H2AX as a surrogate marker for DNA damage, we found that mequindox treatment induced cellular DNA damage, which paralleled the chemical-induced elevation of reactive oxygen species (ROS) levels. Importantly, expression of the antioxidant enzyme catalase partially alleviated these mequindox-associated effects. Taken together, our results suggest that mequindox cytotoxicity is attributable, in part, to its role as a potent inducer of DNA damage via ROS.

Applications:

1.Mequindox is used as an antibiotic drug in livestock; however, its toxicity remains largely unclear. Previously, we investigated metabolic responses of mice to mequindox exposure. In order to evaluate dependences of animal species in response to mequindox insult, we present the metabolic consequences of mequindox exposure in a rat model, by employing the combination of metabonomics and transcriptomics.

2.Metabolic profiling of urine revealed that metabolic recovery is achieved for rats exposed to a low or moderate dose of mequindox, whereas high levels of mequindox exposure trigger liver dysfunction, causing no such recovery. We found that mequindox exposure causes suppression of the tricarboxylic acid cycle and stimulation of glycolysis, which is in contrast to a mouse model previously investigated. In addition, mequindox dosage induces promotion of β-oxidation of fatty acids, which was confirmed by elevated expressions of acox1, hsd17b2, and cpt1a in liver.

3.Furthermore, altered levels of N-methylnicotinate, 1-methylnicotinamide, and glutathione disulfide highlighted the promotion of vitamin B3 antioxidative cycle in rats exposed to mequindox. Moreover, mequindox exposure altered levels of gut microbiotal related co-metabolites, suggesting a perturbation of the gut microflora of the host. Our work provides a comprehensive view of the toxicological effects of mequindox, which is important in the usage of mequindox in animal and human food safety.


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add to favorites ... nanjing Other Email:teresa@chembj.com Natural Powder CAS 875446-37-0 Anacetrapib for Treatmenting of Atherosclerosis
Email:teresa@chembj.com Natural Powder CAS 875446-37-0 Anacetrapib for Treatmenting of Atherosclerosis



 Quick Detail:

Product Name Anacetrapib
Synonyms Anacetrapib;Mk0859;Mk-0859;Unii-p7T269pr6s;(4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-[[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl]-4-methyl-1,3-oxazolidin-2-one
CAS NO 875446-37-0
Einecs No 202-509-5
MF C30H25F10NO3
MW 637.508432
Purity >99%
Appearance Colorless clear oily liquid with acetone-like odor
Product Categories Aromatics;Chiral Reagents;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Anacetrapib;Inhibitor;CETP inhibitor;875446-37-0
Lead time Within 24 hours upon receipt of payment
Shipment EMS, DHL, TNT, FedEx, UPS
Uses An orally active and potent cholesterol ester transfer protein (CETP) inhibitor for the treatment of atherosclerosis, in particular dyslipidemia

Product Description:

Anacetrapib, also known as MK-0859, is a potent and selective inhibitor of cholesteryl ester transfer protein (CETP) that exhibits strong inhibition against CETP-mediated transfer of cholesteryl esters and triglycerides with values of inhibition constant IC50 of 16 nM and 29 nM respectively. Anacetrapib is mainly metabolized by CYP3A4 through O-demethylation, hydroxylation on the biphenyl moiety and hydroxylation on the isopropyl side chain resulting in three oxidative metabolites M1, M2 and M3 respectively. Anacetrapib is being investigated for the treatment of primary hypercholesterolemia and mixed hyperlipidemia due to its impressive effects to lower low-density lipoprotein (LDL) cholesterol levels and increase high-density lipoprotein (HDL) cholesterol levels without any associated major adverse events.

Application:

1.Anacetrapib is a cholesteryl ester transfer protein (CETP) inhibitor currently in Phase III of development as a treatment for those with dyslipidemia and the risk of cardiovascular disease. The agent acts by inhibiting the CETP, which mediates the transfer of cholesterol esters from high-density lipoprotein cholesterol (HDL-C) to other lipoproteins. HDL-C has been inversely linked to cardiac risk and is thus a potential target for decreasing residual cardiovascular risk, which remains despite aggressive low-density lipoprotein cholesterol therapy with statin drugs.

2.Anacetrapib has been shown to raise HDL-C by up to 138% and decrease low-density lipoprotein cholesterol by up to 39% compared with placebo. The HDL-C molecules treated with anacetrapib have also been shown to retain their function in cholesterol efflux and reverse cholesterol transport and their anti-inflammatory properties. Unlike the previously tested CETP inhibitor torcetrapib, anacetrapib has not been shown to elevate blood pressure, alter electrolytes, or cause any significant side effects. Future studies will determine whether these alterations in the lipid profile decrease the cardiovascular risk of morbidity and mortality. If these studies show promising results, anacetrapib could become a vital pharmacologic therapy for decreasing cardiovascular risk in patients.


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add to favorites ... nanjing Other Email:teresa@chembj.com 99% Purity Sarms Powder CAS 317318-84-6 Gw-0742/Gw610742
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99% Purity Sarms Powder CAS 317318-84-6 Gw-0742/Gw610742 Email:teresa@chembj.com


Quick Detail:

Product Name GW0742
CAS 317318-84-6
Synonyms GW0742;[4-[[[2-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-5-THIAZOLYL]METHYL]THIO]-2-METHYLPHENOXY]ACETIC ACID;4-[2-(3-FLUORO-4-TRIFLUOROMETHYL-PHENYL)-4-METHYL-THIAZOL-5-YLMETHYLSULFANYL]-2-METHYL-PHENOXY-ACETIC ACID;4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]AceticAcid;4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethylsulfanyl]- 2-methyl-phenoxy}-acetic acid;Acetic acid, 2-[4-[[[2-[3-fluoro-4-(trifluoroMethyl)phenyl]-4-Methyl-5-thiazolyl]Methyl]thio]-2-Methylphenoxy]-;2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy);GW 0742X
Alias Testosterone Cyclopentylpropionate
Purity 98%
MF C21H17F4NO3S2
MW 471.49
mp  134.5-135.5 °C
storage temp 2-8°C
Color  Light Yellow
Appearance Light Yellow Solid
Brand NJBN STEROID
Price Negotiated
Shipment EMS, FedEx, TNT, DHL, UPS
Delivery within 1 day after we get the payment
Product Categories AllInhibitors;Inhibitors;Intermediates&FineChemicals;Pharmaceuticals;Intracellular receptor;Inhibitor
Usage A small molecule agonist of the human Peroxisome Proliferator-Activated Recept d (PPAR d). It shows an EC50 of 1.1 nM against PPAR d with 100-fold selectivity over the other human subtypes
 
Product Description:

1.GW0742 is a synthetic, potent and selective PPAR-β/δ agonist. PPARs are ligand-dependent transcription factors which are involved in many physiological processes, such as inflammation and energy homeostasis. PPAR-β/δ is one of three PPARs in the nuclear hormone receptor superfamily that are collectively involved in the control of lipid homoeostasis among other functions. GW0742 can attenuate the increase of PARP activity that caused by SAO shock. GW0742 is also able to prevent radiation-induced brain injury in C57Bl/6 wild-type (WT) and PPARδ knockout (KO) mice. Dietary GW0742 can prevent the acute increase in IL-1β mRNA and ERK phosphorylation measured at 3 h after a single 10-Gy dose of WBI as well as the increase in the number of activated hippocampal microglia 1 week after WBI.
Reference
Rosanna Di Paola, Emanuela Esposito, Emanuela Mazzon, Irene Paterniti, Maria Galuppo, Salvatore Cuzzocrea. GW0742, a selective PPAR-β/δ agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury. August 2010. Journal of Leukocyte Biology. vol. 88 no. 2 291-301
Caroline I. Schnegg, Dana Greene-Schloesser, Mitra Kooshki, Valerie S. Payne, Fang-Chi Hsud, Mike E. Robbins. hippocampal-dependent cognitive impairment after whole-brain irradiation. Free Radical Biology and Medicine. Volume 61, August 2013, Pages 1-9.


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add to favorites ... nanjing Other Email:teresa@chembj.com CAS 144701-48 Raw Material Steroid Powder Hypotensive Function Telmisartan
Email:teresa@chembj.com CAS 144701-48 Raw Material Steroid Powder Hypotensive Function Telmisartan


Quick Detail:

Product name Telmisartan
Synonyms TU-199;TELMISARTAN;PRITOR;MICARDIS;BIBR 277;4'[(1,4'-DIMETHYL-2'-PROPYL[2,6'-BI-1H-BENZIMIDAZOL]-1'-YL)METHYL][1,1'-BIPHENYL]-2-CARBOXYLIC ACID;4'-[(1,4'-DIMETHYL-2'-PROPYL[2,6'-BI-H-BENZIMIDAZOL]-1'-YL)METHYL][1,1'-BIPHENYL]-2-CARBOXYLIC ACID;3-methoxy-8-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl sulfinyl]-2,7,9-triazabicyclo[4.3.0]nona-2,4,8,10-tetraene
CAS NO 144701-48-4
MF C33H30N4O2
MW 514.63
Appearance White or off white crystalline powder
Assay 99%min
Storage Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Brand Name NJBN STEROID
Delivery EMS, DHL, TNT, FedEx, UPS
Delivery time within 24 hours upon receipt of payment
Product Category Pharmaceutical material and intermeidates;Active Pharmaceutical Ingredients;INTERMEDIATESOF;Antihypertensive;Imidazoles;(intermediates of telmisartan);Telmisartan;Hypertension;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Other Products;Hypertension.;CARADRIN
Usage It can be used as anti-hypertensive drugs and vasodilator hormone antagonist.
 
 Product Description:

1.Telmisartan is a member of a family of drugs called angiotensin receptor blockers (ARBs), which includes losartan (Cozaar), valsartan (Diovan), irbesartan (Avapro), and candesartan (Atacand). Angiotensin, formed in the blood by the action of angiotensin converting enzyme (ACE), is a powerful chemical that attaches to angiotensin receptors found in many tissues but primarily on muscle cells of blood vessels. Angiotensin's attachment to the receptors causes muscle cells to shorten and narrow the blood vessels (vasoconstrict), which leads to an increase in blood pressure (hypertension). Telmisartan blocks the angiotensin receptor. By blocking the action of angiotensin, telmisartan widens blood vessels (vasodilate) and reduces blood pressure. Telmisartan was approved by the FDA in November 2000.

2.Telmisartan is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure can reduce the risk of strokes and heart attacks.Telmisartan is also used to lower the risk of heart attacks or stroke in patients 55 years of age and older who have diabetes or heart problems.Telmisartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes blood vessels to tighten. As a result, telmisartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.

 Applications:

Telmisartan (Micardis®) is a prescription medicine that has been licensed to treat high blood pressure (hypertension) in adults. It is also approved to reduce the risk of heart attacks.Telmisartan is used for the treatment of hypertension (high blood pressure). It also is used for reducing the risk of heart attack, stroke, or death from cardiovascular causes in patients 55 years of age or older at high risk of developing major cardiovascular events but who are unable to take ACE inhibitors.


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add to favorites ... nanjing Other Email:teresa@chembj.com Anabolic Steroid Powder Oral Injectable CAS 3381-88-2 Superdrol for Bodybuilging
Email:teresa@chembj.com Anabolic Steroid Powder Oral & Injectable Superdrol 3381-88-2 for Bodybuilging


Quick Detail:

Product Name:Superdrol
Alias: 2,17-Dimethyldihydrotestosterone , 17-hydroxy-2,17-dimethylandrostan-3-one,Superdrol,17a-Methyl-Drostanolone
Purity : 97%min
CAS Registry Number: 3381-88-2
MF : C21H34O2
MW : 318.4935 
Grade : Pharmaceutical Grade
Storage: Shading, confined preservation
Delivery time :within 24 hours upon receipt of payment
Delivery: EMS, DHL, TNT, FedEx, UPS
Usage : Its tumor inhibiting properties , and it is noted as being a "potent orally active anabolic agent exhibiting only weak androgenic activity

Product Description: 

1.Superdrol is an oral anabolic steroid.For bodybuilding/athletic purposes Superdrol increases testosterone levels which induce substantial increases in bodily shape and size, largely due to its ability to increase your number of muscle fibers.

2.These benefits alone make Superdrol a formidable androgen, but it also encompasses other traditional steroid properties like: increased red blood cell (RBC) production; improved endurance during exercise via better lactic acid clearing; enhanced oxygen and nutrient delivery to working muscles for greater stamina; better muscle glycogen restoration after exercise for faster recovery and; the inhibition of catabolism (muscle destruction).



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add to favorites ... nanjing Other Email:teresa@chembj.com Inhibite Thrombin-Mediated Platelet Activation CAS 128270-60-0 Bivalirudin Trifluoroacetate for Aggregation
Email:teresa@chembj.com Inhibite Thrombin-mediated Platelet Activation CAS 128270-60-0 Bivalirudin Trifluoroacetate for Aggregation


Quick Detail:

Product Name:Bivalirudin Trifluoroacetate
Sequence:D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH
Alias:126:PN:WO2004076484PAGE:31 claimed protein;Angiomax;BG 8967;Bivalirudin;Hirulog; Hirulog 1
Cas No.: 128270-60-0
Molecular Formula: C98H138N24O33
Molecular Weight: 2180.29
Purity (HPLC): 98.0%min.
Appearance: White Powder
Single Impurity (HPLC): 1.0%max
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): >80.0%
Water Content (Karl Fischer): <8.0%
TrifluoroAcetate Content(HPIC): >12.0%
MS (ESI): Consistent
Mass Balance: 95.0~105.0%
Grade : Pharmaceutical Grade
Storage: Closed, below 2 ~ 8ºC preservation 
Brand Name:NJBN STEROID
Delivery time : within 24 hours upon receipt of payment
Delivery: EMS, DHL, TNT, FedEx, UPS
Usage : This product is mainly used for the prevention of vascular forming interventional therapy in the treatment of unstable angina, ischemic complications before and after.It inhibits both circulating and clot-bound thrombin, while also inhibiting thrombin-mediated platelet activation and aggregation.
 
Description:

1.Bivalirudin (Angiomax or Angiox, manufactured by The Medicines Company) is a specific and reversible direct thrombin inhibitor (DTI).Bivalirudin is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. Bivalirudin is a short, synthetic peptide that is potent, highly specific, and a reversible inhibitor of thrombin. It inhibits both circulating and clot-bound thrombin, while also inhibiting thrombin-mediated platelet activation and aggregation.  Bivalirudin has a quick onset of action and a short half-life. It does not bind to plasma proteins (other than thrombin) or to red blood cells.

2.Therefore it has a predictable antithrombotic response. There is no risk for Heparin Induced Thrombocytopenia/Heparin Induced Thrombosis-Thrombocytopenia Syndrome (HIT/HITTS). It does not require a binding cofactor such as antithrombin and does not activate platelets. These characteristics make bivalirudin an ideal alternative to heparin.Bivalirudin clinical studies demonstrated consistent positive outcomes in patients with stable angina, unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) undergoing PCI in 7 major randomized trials

Application:

Bivalirudin is indicated for use as an anticoagulant in patients with unstable angina undergoing percutaneous transluminal coronary angioplasty (PTCA).Bivalirudin with provisional use of glycoprotein IIb/IIIa inhibitor (GPI) is indicated for use as an anticoagulant in patients undergoing percutaneous coronary intervention (PCI).Bivalirudin is indicated for patients with, or at risk of HIT/HITTS undergoing PCI.Bivalirudin is intended for use with aspirin and has been studied only in patients receiving concomitant aspirin.



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add to favorites ... nanjing Other Email:teresa@chembj.com CAS 94-24-6 Analgesic Local Anesthesia Treat Premature Ejaculation Tetracaine
Email:teresa@chembj.com CAS  94-24-6  Analgesic Local Anesthesia Treat Premature Ejaculation Tetracaine


Quick Detail:

Product Name Tetracaine
Mol File 94-24-6.mol
Chemical Names Tetracaine; Amethocaine; 94-24-6; Pontocaine; Dicaine; Niphanoid;
CAS No 94-24-6
EINECS 202-316-6
Assay 99%
MF C15H24N2O2
MW 264.36
Appearance White or off-white crystalline powder
Packing 1kg/aluminium foil bag or as required
Minimum order quantity 40g
Drug Class Injectable steroid,oral steroid, bodybuilding steroid
Delivery time Within 24 hours upon receipt of payment
Shipping EMS , DHL , TNT , FedEx , UPS
Brand NJBN STEROID
Categories Pharmaceutical; Active Pharmaceutical Ingredients; Biochemistry; Steroids
Usage analgesic
 
 Product Description:
 
1.Tetracaine is a local anesthetic (numbing medicine). It works by blocking nerve signals in your body.
Tetracaine topical (for the skin) is used to numb different parts of the body before a medical test or procedure.
Tetracaine topical may also be used for purposes not listed in this medication guide.
2.Tetracaine is a topical local anesthetic for the eyes. Tetracaine works by interfering with entry of sodium ions into nerve cells. This reduces the ability of nerves to generate an impulse and send pain sensations.
3.Tetracaine is prescribed as local anesthetic before eye procedures like tonometry, gonioscopy, removal of corneal foreign bodies, and for short corneal and conjunctival procedures. Note that most patients are not prescribed tetracaine for home use because the drug may potentially mask symptoms that require early evaluation by an ophthalmologist.
 
Applications:
 
1.Tetracaine can be used as a research tool for studying E-C coupling in both skeletal as well as cardiac muscle.[] The product is a local anaesthetic drug used for studying the impact of numerous drugs on Tumour-necrosis-factor (TNF)-mediated cytotoxicity as well as TNF-induced arachidonic acid release.Local surface, conduction and infiltration anaesthetic or contact anaesthetic of the benzoate ester type. It acts on the neuronal membrane by inhibiting excitation and conduction.
2.Tetracaine also refers as 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester interfere with calcium movement in muscle and non-muscle cells and can inhibit potassium-induced as well as caffeine-induced shortening of outer hair cells (OHC′s). But, the product can′t inhibit electrically-induced shortening of OHC′s.[]The product can also stimulate caspase activation and inhibits pro-survival signalling pathways which in turn induce human renal cell apoptosis.
3.Tetracaine treated eyes in both groups (ocular hypertensive and normal controls) demonstrated significant IOP reduction at time zero (immediately after drop instillation) which was sustained up to 20 minutes, as compared to placebo treated eyes (P<0.05). In ocular hypertensive rabbits, repeat instillation of tetracaine significantly reduced IOP at 55 minutes up to 30 minutes thereafter


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add to favorites ... nanjing Other Email:teresa@chembj.com Pharmaceutical Raw Materials Promoting Metabolism of Brain 3685-84-5 Meclofenoxate Hydrochloride
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Email:teresa@chembj.com Pharmaceutical Raw Materials Promoting Metabolism of Brain 3685-84-5 Meclofenoxate hydrochloride 


Quick Details:
 
Product Name: Meclofenoxate hydrochloride
Synonyms: Centrophenoxine hydrochloride; 4-Chlorophenoxy-acetic acid 2-(dimethylamino)ethyl ester hydrochloride
CAS No.: 3685-84-5
EINECS : 222-975-3
Molecular Formula: C12H17Cl2NO3
Molecular Weight:294.17
Appearance: White crystalline powder
Assay: 99%
Usage: Pharmaceutical raw intermediates
 
Description:
 
1.Part of a class of drugs known as nootropic drugs - or 'smart drugs', Centrophenoxine is one of the original anti-ageing, neuro-energizing drugs.The word nootropic itself is derived from the Greek words 'noos' or 'mind' and 'tropein', which means bend or turn.Centrophenoxine is an anti-ageing drug, widely used to increase brain energy. It has been found to be extremely effective in the treatment of brain damage due to old age, stroke or toxic chemicals.
 
2.Centrophenoxine is used to enhance the body's defense against free radical damage caused by ageing. It is particularly useful in the treatment of senile dementia, where regular use can prevent further mental deterioration.Often referred to as an 'ageing reversal drug', Centrophenoxine has been clinically proven to improve memory and increase the speed at which new information is stored and used. It is effective in fighting both cerebral ageing and age-related diseases.
 
Application:
 
1. Promote the metabolism of brain;
2. Clear cells in the fat brown pigment (Lipofuscin);
3. Increase the cerebral blood flow;
4. Improve the ability to remember;
5. The resisting hypoxia;
6. Can promote protein assimilation, enhance the efficacy of other anabolic drugs in the body;
7. Increase in the amount of serotonin in the brain;
8. Promote between depending on the bed bottom can pay - pituitary - renal department between renal cortical hormone secretion; 9. Activate the brain stem reticular structure.



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add to favorites ... nanjing Other Email:teresa@chembj.com Natural Bodybuilding Hormone 601-63-8 Nandrolone Cypionate for Muscle Growth
Email:teresa@chembj.com Natural Bodybuilding Hormone 601-63-8 Nandrolone Cypionate for Muscle Growth


 Quick Detail:



Product Name Nandrolone cypionate
Synonyms 17beta-hydroxyestr-4-en-3-one 17-(3cyclopentylpropionate);NANDROLONE CYPIONATE;NANDROLONE CIPIONATE;Nortestosteronecypionate;NandroloneCypionate/Nandrolone cyclopentanepropionate;17βHydroxyestr4en3one(3cyclopentylpropionate);19-Nortestosterone 3-cyclopentylpropionate;Nandrolone cypiontate
CAS NO 601-63-8
EINECS 210-006-7
MF C26H38O3
MW 398.57812
Character White crystalline powder
Packing Foil bag or tin
Melting point 215.3-226.3°C
MP 215.3-226.3°C
Mol File 601-63-8.mol
Assay 99% min
Grade Pharmaceutical Grade
Delivery time Within 24 hours upon receipt of payment
Shipping EMS, DHL, TNT, FedEx, UPS
Categories Iscellaneous; Biochemistry; Steroids (Others)
Brand NJBN STEROID
Product Categories Steroid and Hormone


 Product Description:

1.Nandrolone Cypionate first appeared in the 1960's around the same time as Nandrolone Decanoate, but would enjoy short-lived success on the human pharmaceutical market. Nandrolone Decanoate, best known by the trade name Deca Durabolin has largely dominated the human Nandrolone marketplace along with Durabolin (Nandrolone Phenylpropionate). However, while short lived on the human market Nandrolone Cypionate has enjoyed some success on the veterinarian market under the name Dynabol.

2.Dynabol first appeared though the veterinarian compounding group Jurox in Australia but would vanish from the market in 2001. In 2002, SYD Group in Australia would obtain all Jurox rights and reintroduce the Dynabol product, but this time under the name Anabolic DN and Anabolic NA. SYD group would also begin manufacturing a much stronger Nandrolone Cypionate, which it introduced to the Mexican veterinarian drug market. However, this venture was short lived as the U.S. DEA charged SYD Group with illegally exporting the compound from Mexico to the U.S. market for off label human use. Since that time the compound can only be found in Australia and under very tight control.

3.While no legitimate pharmaceutical, human or veterinarian Dynabol exists, at least no longer under that brand name, Nandrolone Cypionate can still be found. However, it is a very rare mixture of Nandrolone and largely not sought after as there is so much Nandrolone Decanoate and Nandrolone Phenylpropionate on the market. However, you will find some Underground Labs (UGL's) that make it and regardless of the brand in question most all refer to all Nandrolone Cypionate as Dynabol.

4.For all intense purposes, Dynabol is identical to Deca Durabolin. The total Nandrolone traits will be the same, the possible side effects are identical and the end results should be a mirror. The only notable difference is the Cypionate ester is slightly smaller than the Decanoate ester, which will give Dynabol a slightly faster release time, but not by much. The difference in these two compounds on a functional basis is meaningless. The individual could use Dynabol or Deca Durabolin in a performance or therapeutic setting and receive the same results.


Applications:

1.By now we should be able to see the effects of Dynabol, but we want to look at things in a more realistic sense in order to give you an idea of what to expect. In this case, we will be strongly concentrating on performance enhancement but even through this concentration therapeutic benefits will be understood.

2.For the off-season athlete the effects of Dynabol will be tremendous. In fact, Nandrolone along with testosterone and the possible addition of Anadrol orDianabol is one of the oldest most popular stacks of all time. The individual should be able to gain a lot of muscle mass, and while it won't come fast it will be produced at a steady, even rate. Some do complain about water retention being problematic with Nandrolone and the hormone does aromatize; however, its rate of aromatization is only 20% that of testosterone. By controlling ones diet, which many fail to do in the off-season as well as using an anti-estrogen, water retention should not be an issue. The individual should also find he gains his new mass with less body fat accumulation that would otherwise occur due to the metabolic enhancement provided.

3.Very few think of Dynabol or any Nandrolone compound for that matter as a cutting steroid, at least very few gym rats and recreational steroid users. However, this can be a very common steroid in competitive bodybuilding circles during contest prep time, and odds are strong they will be leaner than you'll ever be. Dynabol will provide significant protection to your lean mass. In order to lose body fat, you must burn more calories than you consume. This puts lean tissue at risk as the body will often take from muscle tissue to meet its energy demands. Even with a well-planned diet this will occur, but by enhancing the anabolic atmosphere with compounds like Dynabol this is minimized. Many also use Dynabol or related steroids during a diet for joint relief and overall recovery. Hard training alone is rough on the body, but when very lean it often becomes a little more intense.

4.Dynabol and perhaps more so other Nandrolone compounds are the most popular steroids in performance athletics. Nandrolone has for years been a primary steroid in professional football and has become essential to the game despite fan ignorance. This again goes back to the healing properties and pain relief provided. When we say pain relief, again we're not talking about a masking effect such as through NSAID's or opiates but rather true healing. Then consider the recovery promotion of connective tissue and muscle tissue overall and this steroid becomes invaluable. Further, due to the notable increase in red blood cell count muscular endurance is enhanced, the athlete doesn't tire out as fast, and as a result, a better athlete now exist. Regardless of your reasons for use there is hardly an athlete or individual who cannot benefit from these effects of Dynabol.


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add to favorites ... nanjing Other Email:teresa@chembj.com Otava-Bb 1115529 Pharmaceutical Raw Materials CAS 571190-30-2 Palbociclib
Email:teresa@chembj.com OTAVA-BB 1115529 Pharmaceutical Raw Materials CAS 571190-30-2 Palbociclib



 Quick Detail:

Product Name Palbociclib
Synonyms OTAVA-BB 1115529;PD0332991;6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one;Pyrido(2,3-D)pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)-;6-acetyl-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one;Palbociclib;OTAVA-BB 1115529/PD0332991;OTAVA-BB 1115529
CAS NO 571190-30-2
MF C24H29N7O2
MW 447.54
mp  200 ºC
Product Categories API;Inhibitors
Appearance Light yellow crystal powder
Assay 99%
Brand Name NJBN STEROID
Usage Used with other drugs to treat Breast cancer
 
 Product Description:

1.Palbociclib is used in combination with (Femara) to treat a certain type of hormone receptor-positive, advanced breast cancer (breast cancer that depends on hormones such as estrogen to grow) in women who have experienced menopause (change of life; end of monthly menstrual periods). Palbociclib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells.

2.A new drug for the treatment of breast cancer with a novel mechanism of action, palbociclib (Ibrance) has been granted accelerated approval by the US Food and Drug Administration (FDA), two months ahead of schedule.Palbociclib is indicated for use with the aromatase inhibitor as first-line treatment in postmenopausal women with metastatic breast cancer that is estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative.The new drug acts as an inhibitor of cyclin-dependent kinases 4 and 6, which are involved in promoting the growth of cancer cells, the FDA noted.
"The addition of palbociclib to provides a novel treatment option to women diagnosed with metastatic breast cancer," said Richard Pazdur, MD, director of the Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research.

3.The agency granted the drug breakthrough therapy designation because the sponsor demonstrated through preliminary clinical evidence that the drug may offer a substantial improvement over available therapies, the FDA said. It also received priority review, which provides for expedited review of drugs intended to provide a significant improvement in safety or effectiveness in the treatment of a serious condition or meet an unmet medical need.

Application:

Palbociclib is approved to be used with other drugs to treat:Breast cancer that is hormonereceptor positive (HR+) and HER2 negative(HER2-) and is advanced or has metastasized (spread to other parts of the body).It is used with in women whose disease has gotten worse after treatment with hormone therapy.It is used with letrozole in postmenopausal women who have not been treated with hormone therapy.Palbociclib is also being studied in the treatment of other types of cancer.


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add to favorites ... nanjing Other Email:teresa@chembj.com Bremelanotice Growth Peptides Steroids CAS 19387-91-8 PT-141 Treatment of Sexual Disorder
Bremelanotice Growth Peptides Steroids CAS 19387-91-8 PT-141 Treatment of Sexual Disorder Email:teresa@chembj.com


Quick Details:

Product Name PT 141
Synonyms Tinidazole;VALIDAMINE;6-amino-4-(hydroxymethyl)-4-cyclohexane-[4h,5h]-1,2,3-triol;(1R,2S,3S,4S,6R)-4-Amino-6-(hydroxymethyl)cyclohexane-1,2,3-triol;Pt141 Acetate;Bremelanotide,Acetate;Bremelanotide Acetate;(1R)-4β-Amino-6α-(hydroxymethyl)cyclohexane-1β,2α,3β-triol
CAS NO 32780-32-8
Assay 99%
MF C7H15NO4
MW 177.2
Storage Shading, confined preservation
Related Substances Pharmaceutical Grade
Brand Name NJBN STEROID
Usage Treatment of Sexual Disorder
 
 Product Description:

1.PT-141 is a potential remedy for the treatment of sexual dysfunction; specifically, male erectile dysfunction. Studies have shown that PT-141 does not act on the vascular system like former compounds, but allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation. 

2.PT-141 was developed from the Melanotan 2 Peptide, which underwent testing as a sunless tanning agent. In initial testing, Melanotan 2 did induce tanning, but additionally caused sexual arousal and spontaneous erections as unexpected side effects in nine out of the ten original male volunteer test subjects. Palatin completed patient treatment in its Phase 2B clinical trial in premenopausal women with FSD Primary data analysis and announcement of top-line results anticipated in first-half of fourth quarter of calendar year 2012. In studies, PT-141 was shown to be effective in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder).

Applications:

PT-141 is a synthetic amino acid protein discovered during clinical trials using the Melanotan 2 for sunless tanning, photo-protection results from melanotans. Participants were documented as having experienced aphrodisiac reactions, leading to the further developmentPT-141. The melanocortin system targets receptors associated with desire through the melanocyte stimulating hormone paths that cross the blood-brain-barrier. Potentially the powerful sex-drug results feeling an aphrodisiac experience amplifying arousal pt141 reviews have shown the ability to increase libido effects of both men and women.


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add to favorites ... nanjing Other Email:teresa@chembj.com Top Purity 99% 136-47-0 Tetracaine HCl Anesthetic Anodyne for Anti-Pain
Top Purity 99% 136-47-0 Tetracaine HCl Anesthetic Anodyne for Anti-pain Email:teresa@chembj.com


Quick Detail:

Product Name:Tetracaine HCl
Alias : Tetracaine hydrochloride ,2-Dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride;
4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride
CAS NO. : 136-47-0
EINECS : 205-248-5
MF : C15H25ClN2O2
MW : 300.82
Melting point : 149°C
Assay : 99%
Grade : Pharmaceutical Grade
Storage: Closed, confined and shading preservation 
Brand Name:NJBNSTEROID
Delivery time : within 24  hours upon receipt of payment
Delivery: EMS, DHL, TNT, FedEx, UPS
Usage : Local anesthetic; Mainly used in mucosa anesthetic. The function is stronger than Procaine and Lidocaine.

Description:

Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
 
Application:

Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.


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add to favorites ... nanjing Other Email:teresa@chembj.com 6157-87-5 Pharmaceutical Raw Materials Trestolone Acetate for Bodybuildin
6157-87-5 Pharmaceutical raw materials Trestolone acetate for Bodybuildin
Email:teresa@chembj.com



Quick Detail:

Product Name: Trestolone acetate
CAS No.: 6157-87-5
Synonyms: 17β-Hydroxy-7α-methylestr-4-en-3-one acetate; 3-Oxo-7α-methylestra-4-ene-17β-ol acetate; Acetic acid 3-oxo-7α-methylestra-4-ene-17β-yl ester; NSC-69948; U-15614
Molecular Formula:C21H30O3
Melting Point: 447.571 °C at 760 mmHg
Molecular Weight 330.47
Flash Point: 194.228 °
Density: 1.117 g/cm3
Appearance: White powder
Usage: Pharmaceutical raw materials, bodybuilding and sex enhancement
 
Product Description:
 
1.Chemically speaking, trestolone acetate(MENT) actually an alright looking drug. It doesn't show much interaction with Sex Hormone Binding Globulin, which means that a good portion ought to stay unbound and active in the blood. Also, the drug is a potent binder to the androgen receptor, while showing minimal affinity for the progesterone and mineralocorticoid receptors respectively. Since it is not able to be 5a-reduced into a dihydro-version, it likely wouldn't cause many of the side effects commonly associated with Dihydrotestosterone. This is also a likely reason that it is less apt to cause prostate enlargement, and may even be indicated for the treatment of specific prostate issues.
 
2.The ability of 7 alpha-methyl-19-nortestosterone acetate (MENT) to increase the weights of ventral prostate and seminal vesicles of castrated rats was four times higher than that of testosterone, while its effect on the weights of bulbocavernosus plus levator ani muscles (muscle), was 10 times that of testosterone.Various forms of MENT in human pharmaceutical preparations and devices for contraception and hormone therapy, specifically MENT Ac implant and MENT transdermal gel and patch formulations, are currently under clinical investigation. MENT is absorbed transdermally up to three times the rate of testosterone - 17 methyl testosterone and 17-α methyl testosterone.

3.MENT will have application in a wide range of indications beyond androgen replacement therapy and contraception, including, without limitation, primary hypogonadism, testicular failure, ASIH, baldness, sarcopenia, loss of bone mass, muscle wasting and cachexia, BPH, prostate cancer and of course, bodybuilding and sports performance enhancement.Trestolone acetate is the chemical name of active ingredient in MENT. MENT is a registered trademark of Population Council, Inc. in the United States and/or other countries.


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